This Account is dedicated to Professor Takeo Kawabata on the occasion of his 70th
birthday.
Abstract
Unnatural α,α-disubstituted α-amino acids have played a privileged role in drug discovery
campaigns, and the development of their efficient synthetic methods has thus received
continuous attention. This account describes our originally developed synthetic methods
to obtain α,α-disubstituted α-amino acid derivatives using readily accessible building
blocks.
1 Introduction
2 Asymmetric Synthesis of α,α-Disubstituted α-Aryl α-Amino Acid
Derivatives via ‘Memory of Chirality’
3 Synthesis of Natural-Product-Derived α,α-Disubstituted α-Amino Acid Derivatives
by Chemical Engineering of Natural Product Extracts
4 One-Pot Synthesis of α,α-Disubstituted α-Amino Acid Derivatives by Ammonia-Ugi
Reaction
5 Conclusions
Key words
α,α-disubstituted α-amino acid - memory of chirality - Bucherer–Bergs reaction -
Ugi reaction - ammonia-Ugi reaction - natural product extract
