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Am J Perinatol 2025; 42(10): 1344-1353
DOI: 10.1055/a-2494-2157
Original Article

Relationship between Intrapartum Continuous Glucose Monitoring Values and Neonatal Hypoglycemia in Individuals with Diabetes

Michal Fishel Bartal 
1   Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas
2   Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
,
Sarah A. Nazeer
1   Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas
,
Joycelyn Ashby Cornthwaite
1   Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas
,
Ghamar Bitar 
1   Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas
,
Sean C. Blackwell
1   Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas
,
Claudia Pedroza
3   Center for Clinical Research and Evidence-Based Medicine, The University of Texas Health Science Center at Houston, Houston, Texas
,
Suneet P. Chauhan
4   Delaware Center of Maternal-Fetal Medicine at Christiana Care, Department of Obstetrics, Gynecology, and Reproductive Sciences, Newark, Delaware
,
Antonio Saad
5   Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, Texas
,
George Saade
5   Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, Texas
,
Baha M. Sibai
1   Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas
› Institutsangaben
Funding Study devices were provided by Dexcom Inc. No additional funding was provided. Dexcom had no role in study design, data collection, analysis, interpretation, or manuscript writing.
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Abstract

Objective

We aimed to evaluate the relationship between intrapartum continuous glucose monitoring (CGM) and neonatal hypoglycemia (NH) in individuals with diabetes.

Study Design

a multicenter prospective study (November 2021–December 2022) of laboring individuals with pregestational or gestational diabetes at ≥34 weeks. Cohorts had a blinded CGM placed from admission through delivery and were monitored with fingerstick (FS) according to usual care. The primary outcome was NH. Secondary neonatal outcomes included neonatal intensive care unit (NICU) length of stay, need for intravenous (IV) glucose therapy, hyperbilirubinemia, respiratory distress, or respiratory distress syndrome. Time in the target range (TIR; range 70–110 mg/dL) and time above the target range (TAR; >110 mg/dL) were expressed as a percentage of all CGM readings, and mean glucose was obtained. Youden index was used to choose the cut point for TAR and prediction of NH.

Results

Of 9,479 deliveries during the study period, 202 (2.1%) met the inclusion criteria, and 112 (56%) participants were enrolled (n = 7 did not have available CGM data). Of the study participants, 45 (40%) had pregestational diabetes, and 67 (60%) had gestational diabetes. The mean glucose in labor using a CGM was 102.6 mg/dL (interquartile range [IQR]:89.9, 113.5 mg/dL), and the average percentage of TIR was 62.1% (IQR, 36.9, 85.6). CGM and FS were poor predictors of NH, with no differences in area under the curve (AUC) of mean glucose as a predictor (0.64, 95% CI: 0.48–0.23 vs. 0.53, 95% CI: 0.4–0.6, respectively). The best cut-off for the prediction of NH was a TAR of 61%, with 23% (n = 24) being above the threshold. The rate of NH for TAR >61% versus ≤61% was 45.8 versus 25.9% (p = 0.06). Neonates born to individuals with TAR >61% were more likely to require continuous positive airway pressure after delivery and had a higher cord c-peptide level.

Conclusion

In this prospective study of laboring individuals with diabetes, intrapartum CGM TAR was associated with a higher rate of NH.

Key Points

  • CGM use in labor is feasible with a complete glucose profile in the various stages of labor.

  • Best cut-off for predicting NH was a time above range (≥110 mg/dL) of >61%.

  • CGM and FS were poor predictors of NH.

Keywords

labor - gestational diabetes - pregestational diabetes - neonatal hypoglycemia - intrapartum - delivery

Note

This study was presented as a poster presentation at the Annual Scientific Meeting of the Society for Maternal-Fetal Medicine in Maryland on February 10, 2024.


Supplementary Material



Publikationsverlauf

Eingereicht: 10. November 2024

Angenommen: 01. Dezember 2024

Accepted Manuscript online:
02. Dezember 2024

Artikel online veröffentlicht:
28. Dezember 2024

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