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Am J Perinatol 2025; 42(08): 1051-1058
DOI: 10.1055/a-2457-2721
Original Article

Transplacental Transport Rates of Anti-Pertussis Toxin–IgG and Anti-Filamentous Hemagglutinin–IgG Antibodies in Newborns by Week of Birth

Oguzhan Inceli
1   Department of Obstetrics, Ankara Zekai Tahir Burak Women's Health Training and Research Hospital, Ankara, Türkiye
,
Cemile Sonmez
2   Department of Communicable Diseases Research, Refik Saydam National Public Health Agency, Ankara, Türkiye
,
Elif Ece İnceli
1   Department of Obstetrics, Ankara Zekai Tahir Burak Women's Health Training and Research Hospital, Ankara, Türkiye
,
Hasan Onur Topçu
1   Department of Obstetrics, Ankara Zekai Tahir Burak Women's Health Training and Research Hospital, Ankara, Türkiye
,
Mujde Can Ibanoglu
3   Department of Obstetrics, Etlik Zubeyde Hanim Women's Health Training, and Research Hospital, Ankara, Türkiye
,
Yaprak Engin-Ustun
3   Department of Obstetrics, Etlik Zubeyde Hanim Women's Health Training, and Research Hospital, Ankara, Türkiye
› Author Affiliations Funding None.
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Abstract

Objective

The aim of this study is to investigate the lack of knowledge about the transplacental transport of antibodies in unvaccinated term and preterm infants and possible differences in antibody-mediated immunity in the fetus depending on maternal vaccination in their own infancy.

Study Design

The study was conducted as a prospective cross-sectional study between 2017 and 2018 and included a total of 334 participants. The study included 194 pregnant women with a preterm birth (before 37 weeks) and 140 pregnant women with a term birth. Both umbilical cord blood and maternal blood were used to measure serum levels of anti-pertussis toxin (PT) immunoglobulin (Ig) G and anti-filamentous hemagglutinin (FHA) IgG.

Results

The results showed that anti-FHA IgG antibody levels in the cord blood of women who had delivered at term were significantly higher than those of preterm infants (p = 0.002). The placental transfer rate of anti-PT IgG was higher in women who delivered prematurely, but this difference was not statistically significant (p = 0.128). However, transfer rates for anti-FHA were significantly higher in women who had delivered prematurely (p = 0.001). In addition, transmission rates for both antibodies were found to be significantly lower in women who delivered before 32 weeks gestation than in women who delivered at term (p = 0.006, p < 0.001). Antibody transfer rates were found to be positively correlated with both gestational age and birth weight.

Conclusion

In summary, although placental antibody transfer rates increased with gestational age, transfer rates and antibody levels were low in pregnant women, particularly in women who had given birth before 32 weeks gestation.

Key Points

  • Transport

  • Anti-PT IgG

  • Anti-FHA IgG antibodies

Keywords

filamentous hemagglutinin - pertussis - pertussis toxin - preterm birth - term birth

Ethical Approval

Approval was obtained by the institutional review board from Ankara Zekai Tahir Burak Women's Health Training and Research Hospital on September 19, 2017 (# 96/2017).


Patient Consent

A verbal and written informed consent was obtained from all participants.


Data Availability Statement

Data are openly available in a public repository that issues datasets with DOIs.


Authors' Contributions

All of the authors—O.I., E.E.I., C.S., H.O.T., M.C.I., and Y.E-U.—contributed to the project development, data collection, data analysis, and writing of the manuscript.




Publication History

Received: 03 April 2024

Accepted: 28 October 2024

Article published online:
29 November 2024

© 2024. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 

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