Peptide Synthesis Using Unprotected Amino Acids

Keywords

unprotected amino acids - silacyclic dipeptide - convergent synthesis

Significance

Protecting groups for the N-terminal amino and C-terminal carboxyl groups are essential in peptide synthesis. In this work, the authors have developed peptide bond formation between unprotected amino acids using two kinds of appropriate silylating reagents.

 

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Comment

Me₂Si(Im)₂ and TMSIM were used to achieve peptide bond formation chemoselectively between two different unprotected amino acids to give a broad range of silacyclic dipeptides. Also, silacyclic dipeptides were successfully applied to convergent long peptide synthesis.

 

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Publikationsverlauf

Artikel online veröffentlicht:
21. November 2024