A New General, Mild Preparation of 2-Hydroxy-β-nitrostyrenes Starting from 2-Acetylsalicylaldehydes and Nitroalkanes via Domino Process

Abstract

A new practical and improved preparation of 2-hydroxy-β-nitrostyrenes by reaction of nitroalkanes with acetylsalicylaldehydes, promoted by DBU in acetonitrile at 0 °C is reported. Under these conditions products were isolated in very good yields and as single E-diastereomers.

Key words

nitroalkenes - Henry reaction - domino reaction - nitroaldol condensation - β-nitrostyrenes

Publikationsverlauf

Eingereicht: 11. August 2024

Angenommen nach Revision: 10. September 2024

Accepted Manuscript online:
10. September 2024

Artikel online veröffentlicht:
01. Oktober 2024

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