Iron(III)-Catalysed Povarov Cyclisation for the Synthesis of Fused Dibenzo[b,f][1,7]naphthyridine Embedded Arylpyrrolo Scaffolds

Abstract

An FeCl₃-catalyzed Povarov reaction for the efficient synthesis of dibenzo[b,f][1,7]naphthyridines utilizing 1-(2-alkynylaryl)-2-pyrrolecarbaldehydes and arylamines in excellent yields is demonstrated. The essential features of the present strategy are easy preparation of substrates, broad substrate scope, mild reaction conditions, and high atom economy and yields, in the presence of environmentally friendly iron catalysis.

Key words

arylpyrrolecarbaldehydes - phosphorus oxychloride - arylamines - 1,7-naphthyridines - ferric chloride

Publikationsverlauf

Eingereicht: 11. Mai 2024

Angenommen nach Revision: 20. Juni 2024

Accepted Manuscript online:
20. Juni 2024

Artikel online veröffentlicht:
15. Juli 2024

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