Oxidative Cross-Dehydrogenative C–H Bond Amination of Imidazo[1,2-a]pyridines in Aqueous Media under Metal-Free Conditions

Durgesh Sarothiya; Umesh A. Kshirsagar

doi:10.1055/a-2348-4764

Synthesis, Table of Contents

Synthesis 2024; 56(19): 3019-3026
DOI: 10.1055/a-2348-4764

paper

Oxidative Cross-Dehydrogenative C–H Bond Amination of Imidazo[1,2-a]pyridines in Aqueous Media under Metal-Free Conditions

Durgesh Sarothiya

,

Umesh A. Kshirsagar∗

Abstract

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Abstract

The metal-free direct oxidative cross-dehydrogenative C–H bond amination of imidazopyridines with pyrazole in water as solvent has been developed under K₂S₂O₈-promoted mild conditions. This strategy was applied to variable imidazoheterocycles to give amination products in moderate to good yields. The described protocol also offers scale-up synthesis for the construction of C–N bonds, which makes it suitable for the synthesis of biologically active compounds and pharmaceuticals.

Key words

Heterocycles - Green solvent - Metal-Free - Oxidative coupling - CDC

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References

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