The metal-free direct oxidative cross-dehydrogenative C–H bond amination of imidazopyridines
with pyrazole in water as solvent has been developed under K2S2O8-promoted mild conditions. This strategy was applied to variable imidazoheterocycles
to give amination products in moderate to good yields. The described protocol also
offers scale-up synthesis for the construction of C–N bonds, which makes it suitable
for the synthesis of biologically active compounds and pharmaceuticals.
Key words
Heterocycles - Green solvent - Metal-Free - Oxidative coupling - CDC