Synthesis 2024; 56(19): 3019-3026
DOI: 10.1055/a-2348-4764
paper

Oxidative Cross-Dehydrogenative C–H Bond Amination of Imidazo[1,2-a]pyridines in Aqueous Media under Metal-Free Conditions

Durgesh Sarothiya
,
Umesh A. Kshirsagar

This work was supported by the Govt. of India, provided through the CSIR research grant (02/0486/23/EMR-II).


Abstract

The metal-free direct oxidative cross-dehydrogenative C–H bond amination of imidazopyridines with pyrazole in water as solvent has been developed under K2S2O8-promoted mild conditions. This strategy was applied to variable imidazoheterocycles to give amination products in moderate to good yields. The described protocol also offers scale-up synthesis for the construction of C–N bonds, which makes it suitable for the synthesis of biologically active compounds and pharmaceuticals.

Supporting Information



Publication History

Received: 27 March 2024

Accepted after revision: 19 June 2024

Accepted Manuscript online:
19 June 2024

Article published online:
10 July 2024

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