Abstract
This review highlights the multifaceted usefulness of o-halobenzyl halides as pivotal substrates for the construction of five- to nine-membered
cyclic structures with the aid of transition metals as catalysts. These privileged
entities engage dual active sites, enabling the combination of both intermolecular
benzylation and intramolecular arylation strategies that directs the formation of
a diverse repository of cyclic structures. The introduction of transition-metal catalysis
in cross-coupling transformations sparked a revolution in forging aryl–heteroatom
bonds, culminating in the evolution of more potent methodologies for the synthesis
of a wide spectrum of valuable compounds. Furthermore, the associated pharmaceutical
and biological attributes of these cyclic structures augment their significance in
medicinal chemistry research. This review aims to showcase the importance of this
synthetic methodology and its far-reaching applications in synthesis.
1 Introduction
2 Synthesis of Five-Membered Rings
3 Synthesis of Six-Membered Rings
4 Synthesis of Seven-Membered Rings
5 Synthesis of Eight- and Nine-Membered Rings
6 Conclusion
Key words
C–N bond formation - C–C bond formation - C–O bond formation - C–S bond formation
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o-halobenzyl halides - transition-metal catalysis
