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Synlett
DOI: 10.1055/a-2293-3243
letter

Rapid Cyclic Acetal and Cyclic Ketal Synthesis Assisted by a Rotary Evaporator

Fuyao Jiang‡
a   Department of Chemistry, Xi‘an-Jiaotong Liverpool University, Suzhou, Jiangsu Province, 215123, P. R. of China
b   Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, UK
,
Yinzhe Chen‡
a   Department of Chemistry, Xi‘an-Jiaotong Liverpool University, Suzhou, Jiangsu Province, 215123, P. R. of China
c   Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 7BE, UK
,
Weiding Wang
a   Department of Chemistry, Xi‘an-Jiaotong Liverpool University, Suzhou, Jiangsu Province, 215123, P. R. of China
c   Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 7BE, UK
,
Qian Zhang  ∗
a   Department of Chemistry, Xi‘an-Jiaotong Liverpool University, Suzhou, Jiangsu Province, 215123, P. R. of China
b   Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, UK
› Author AffiliationsThis work was supported by the Research Development Fund (RDF-20-02-30), PGRS2112027, and FOSA2212021) from Xi’an Jiaotong-Liverpool University.
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Abstract

Herein, we present a rapid and efficient method for synthesizing cyclic acetals and ketals utilizing a rotary evaporator. Unlike the conventional Dean–Stark dehydration process, which typically demands extended reaction times and copious amounts of organic solvents, our approach affords the synthesis of cyclic acetals and ketals with varying ring sizes in 30 min while using minimal quantities of dimethyl sulfoxide as the solvent. This innovative protocol features high yields, fast reactions, easy operation, and broad substrate applicability.

Key words

cyclic acetal - cyclic ketal - dehydrative reaction - rotary evaporator - rotavap-assisted synthesis

Supporting Information

    Supporting information for this article is available online at https://doi.org/10.1055/a-2293-3243.
  • Supporting Information


Publication History

Received: 01 March 2024

Accepted after revision: 22 March 2024

Accepted Manuscript online:
22 March 2024

Article published online:
08 April 2024

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