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Synthesis 2024; 56(03): 482-486
DOI: 10.1055/a-2201-3503
DOI: 10.1055/a-2201-3503
paper
Base-Catalyzed Deprotection of Aldehydes: A New Haloform Reaction
We are grateful for financial support from the Natural Science Foundation of Xinjiang Uygur Autonomous Region of China (Grant no. 2022D01A207).
Abstract
An efficient procedure for the deprotection of α,α,α-trihalogen (Cl, Br) methyl alcohols under mild reaction conditions to produce the corresponding aldehydes and haloforms is described. This method can be applied to the deprotection of aromatic, aliphatic, and heterocyclic trihalomethyl alcohol compounds.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2201-3503.
- Supporting Information
Publication History
Received: 24 September 2023
Accepted after revision: 30 October 2023
Accepted Manuscript online:
30 October 2023
Article published online:
04 December 2023
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