RSS-Feed abonnieren
DOI: 10.1055/a-2188-3718
Traditionelle Chinesische Medizin in der Onkologie: wissenschaftliche Evidenz und Leitlinien

Summary
Die Traditionelle Chinesische Medizin (TCM) hat in den letzten Jahrzehnten weltweit Aufmerksamkeit auf sich gezogen, auch in der Onkologie. Hier werden zum Beispiel Akupunktur und Akupressur eingesetzt, um Beschwerden wie Übelkeit oder Fatigue zu lindern. Auch chinesische Arzneimittel werden zur Linderung von Nebenwirkungen angewandt, die etwa im Rahmen einer Chemotherapie auftreten. Dieser Artikel bietet eine Übersicht, welche Therapien der TCM in der Onkologie bereits leitliniengestützt zum Einsatz kommen und für welche Therapien noch wissenschaftliche Belege erarbeitet werden müssen.
Publikationsverlauf
Artikel online veröffentlicht:
12. Dezember 2023
© 2023. Thieme. All rights reserved.
© Karl F. Haug Verlag in MVS Medizinverlage Stuttgart GmbH & Co.
KG
-
Literatur
- 1 Leitlinienprogramm Onkologie, Deutsche Krebsgesellschaft, Deutsche Krebshilfe. Komplementärmedizin in der Behandlung von onkologischen PatientInnen [Internet]. Kurzversion 1.1 – September 2021; AWMF-Registernummer: 032/055OL. Im Internet. https://www.leitlinienprogramm-onkologie.de/leitlinien/komplementaermedizin/ Stand: 25.09.2023
- 2 Lu CL, Li X, Zhou HM. et al Traditional Chinese medicine in cancer care: An overview of 5834; randomized ontrolled trials published in Chinese. Integr Cancer Ther. 2021 20. 15347354211031650
- 3 Liu S, Wang Z, Su Y. et al A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis. Nature 2021; 598 7882 641-645
- 4 Aapro M, Molassiotis A, Dicato M. et al The effect of guideline-consistent antiemetic therapy on chemotherapy-induced nausea and vomiting (CINV): The Pan European Emesis Registry (PEER). Ann Oncol Off J Eur Soc Med Oncol 2012; 23 (08) 1986-1992
- 5 Rithirangsriroj K, Manchana T, Akkayagorn L. Efficacy of acupuncture in prevention of delayed chemotherapy induced nausea and vomiting in gynecologic cancer patients. Gynecol Oncol 2015; 136 (01) 82-86
- 6 Zhou J, Fang L, Wu WY. et al The effect of acupuncture on chemotherapy-associated gastrointestinal symptoms in gastric cancer. Curr Oncol 2017; 24 (01) e1-e5
- 7 Garcia MK, Mcquade J, Haddad R. et al Systematic review of acupuncture in cancer care: A synthesis of the evidence. J Clin Oncol 2013; 31 (07) 952-960
- 8 Miao J, Liu X, Wu C. et al Effects of acupressure on chemotherapy-induced nausea and vomiting – A systematic review with meta-analyses and trial sequential analysis of randomized controlled trials. Int J Nurs Stud 2017; 70: 27-37
- 9 He Y, Guo X, May BH. et al Clinical evidence for association of acupuncture and acupressure with improved cancer pain: A systematic review and meta-analysis. JAMA Oncol 2020; 06 (02) 271-278
- 10 Hershman DL, Unger JM, Greenlee H. et al Effect of acupuncture vs sham acupuncture or waitlist control on joint pain related to aromatase inhibitors among women with early-stage breast cancer: A randomized clinical trial. JAMA 2018; 320 (02) 167-176
- 11 Ntritsou V, Mavrommatis C, Kostoglou C. et al Effect of perioperative electroacupuncture as an adjunctive therapy on postoperative analgesia with tramadol and ketamine in prostatectomy: A randomised sham-controlled single-blind trial. Acupunct Med 2014; 32 (03) 215-222
- 12 D’Alessandro EG, Nebuloni Nagy DR, De Brito CMM. et al Acupuncture for chemotherapy-induced peripheral neuropathy: A randomised controlled pilot study. BMJ Support Palliat Care. 2022; 12 (01) 64-72
- 13 Rostock M, Jaroslawski K, Guethlin C. et al Chemotherapy-induced peripheral neuropathy in cancer patients: A four-arm randomized trial on the effectiveness of electroacupuncture. Evid Based Complement Alternat Med 2013; 2013: 349653
- 14 Wilkes G. Peripheral neuropathy related to chemotherapy. Semin Oncol Nurs 2007; 23 (03) 162-173
- 15 Thornton P.. Oxaliplatin side effects: Common, severe, long term (24.10.2022). Im Internet. https://www.drugs.com/sfx/oxaliplatin-side-effects.html Stand: 26.09.2023
- 16 Hausheer FH, Schilsky RL, Bain S. et al Diagnosis, management, and evaluation of chemotherapy-induced peripheral neuropathy. Semin Oncol 2006; 33 (01) 15-49
- 17 Ju ZY, Wang K, Cui HS. et al Acupuncture for neuropathic pain in adults. Cochrane database Syst Rev 2017; 12 (12)
- 18 Molassiotis A, Suen LKP, Cheng HL. et al A randomized assessor-blinded wait-list-controlled trial to assess the effectiveness of acupuncture in the management of chemotherapy-induced peripheral neuropathy. Integr Cancer Ther 2019; 18: 1534735419836501
- 19 Greenlee H, Crew KD, Capodice J. et al Randomized sham-controlled pilot trial of weekly electro-acupuncture for the prevention of taxane-induced peripheral neuropathy in women with early stage breast cancer. Breast Cancer Res Treat 2016; 156 (03) 453-464
- 20 Lu W, Giobbie-Hurder A, Freedman RA. et al Acupuncture for chemotherapy-induced peripheral neuropathy in breast cancer survivors: A randomized controlled pilot trial. Oncologist 2020; 25 (04) 310-318
- 21 Friedemann T, Kark E, Cao N. et al Acupuncture improves chemotherapy-induced neuropathy explored by neurophysiological and clinical outcomes – The randomized, controlled, cross-over ACUCIN trial. Phytomedicine 2022; 104: 154294
- 22 Zeng Y, Luo T, Finnegan-John J. et al Meta-analysis of randomized controlled trials of acupuncture for cancer-related fatigue. Integr Cancer Ther 2014; 13 (03) 193-200
- 23 Jang A, Brown C, Lamoury G. et al The effects of acupuncture on cancer-related fatigue: Updated systematic review and meta-analysis. Integr Cancer Ther 2020; 19: 1534735420949679
- 24 Duong N, Davis H, Robinson PD. et al Mind and body practices for fatigue reduction in patients with cancer and hematopoietic stem cell transplant recipients: A systematic review and meta-analysis. Crit Rev Oncol Hematol 2017; 120: 210-216
- 25 Khanghah AG, Rizi MS, Nabi BN. et al Effects of acupressure on fatigue in patients with cancer who underwent chemotherapy. J Acupunct Meridian Stud 2019; 12 (04) 103-110
- 26 Zick SM, Sen A, Wyatt GK. et al Investigation of 2 types of self-administered acupressure for persistent cancer-related fatigue in breast cancer survivors: A randomized clinical trial. JAMA Oncol 2016; 02 (11) 1470-1476
- 27 Pan Y, Yang K, Shi X. et al Clinical benefits of acupuncture for the reduction of hormone therapy-related side effects in breast cancer patients: A systematic review. Integr Cancer Ther 2018; 17 (03) 602-618
- 28 Hervik JB, Stub T. Adverse effects of non-hormonal pharmacological interventions in breast cancer survivors, suffering from hot flashes: A systematic review and meta-analysis. Breast Cancer Res Treat 2016; 160 (02) 223-236
- 29 Walker EM, Rodriguez AI, Kohn B. et al Acupuncture versus venlafaxine for the management of vasomotor symptoms in patients with hormone receptor-positive breast cancer: A randomized controlled trial. J Clin Oncol 2010; 28 (04) 634-640
- 30 Frisk J, Källström AC, Wall N. et al Acupuncture improves health-related quality-of-life (HRQoL) and sleep in women with breast cancer and hot flushes. Support Care Cancer 2012; 20 (04) 715-724
- 31 Bokmand S, Flyger H. Acupuncture relieves menopausal discomfort in breast cancer patients: A prospective, double blinded, randomized study. Breast 2013; 22 (03) 320-323
- 32 Garland SN, Xie SX, Li Q. et al Comparative effectiveness of electro-acupuncture versus gabapentin for sleep disturbances in breast cancer survivors with hot flashes: A randomized trial. Menopause 2017; 24 (05) 517-523
- 33 Garland SN, Xie SX, DuHamel K. et al Acupuncture versus cognitive behavioral therapy for insomnia in cancer survivors: A randomized clinical trial. J Natl Cancer Inst 2019; 111 (12) 1323-1331
- 34 Furness S, Bryan G, Mcmillan R. et al Interventions for the management of dry mouth: Non-pharmacological interventions. Cochrane Database Syst Rev 2013 2013: 9
- 35 Assy Z, Brand HS. A systematic review of the effects of acupuncture on xerostomia and hyposalivation. BMC Complement Altern Med 2018; 18 (01) 57
- 36 Leitlinienprogramm Onkologie, Deutsche Krebsgesellschaft, Deutsche Krebshilfe. Leitlinie Supportive Therapie bei onkologischen PatientInnen. Langversion 1.3 – Februar 2020; AWMF-Registernummer: 032/054OL (2/2020). Im Internet. https://www.leitlinienprogramm-onkologie.de/fileadmin/user_upload/Downloads/Leitlinien/Supportivtherapie/LL_Supportiv_Langversion_1.3.pdf Stand: 26.10.2023
- 37 Jung SY, Chae HD, Kang UR. et al Effect of acupuncture on postoperative Ileus after distal gastrectomy for gastric cancer. J Gastric Cancer 2017; 17 (01) 11-20
- 38 Molassiotis A, Bardy J, Finnegan-John J. et al Acupuncture for cancer-related fatigue in patients with breast cancer: A pragmatic randomized controlled trial. J Clin Oncol 2012; 30 (36) 4470-4476
- 39 Bao T, Cai L, Snyder C. et al Patient-reported outcomes in women with breast cancer enrolled in a dual-center, double-blind, randomized controlled trial assessing the effect of acupuncture in reducing aromatase inhibitor-induced musculoskeletal symptoms. Cancer 2014; 120 (03) 381-389
- 40 Mao JJ, Farrar JT, Bruner D. et al Electroacupuncture for fatigue, sleep, and psychological distress in breast cancer patients with aromatase inhibitor-related arthralgia: A randomized trial. Cancer 2014; 120 (23) 3744-3751
- 41 Tong T, Pei C, Chen J. et al Efficacy of acupuncture therapy for chemotherapy-related cognitive impairment in breast cancer patients. Med Sci Monit 2018; 24: 2919-2927
- 42 Pan-Weisz TM, Kryza-Lacombe M, Burkeen J. et al Patient-reported health-related quality of life outcomes in supportive-care interventions for adults with brain tumors: A systematic review. Psychooncology 2019; 28 (01) 11-21
- 43 Brinkhaus B, Kirschbaum B, Stöckigt B. et al Prophylactic acupuncture treatment during chemotherapy with breast cancer: A randomized pragmatic trial with a retrospective nested qualitative study. Breast Cancer Res Treat 2019; 178 (03) 617-628
- 44 Yennurajalingam S, Tannir NM, Williams JL. et al A double-blind, randomized, placebo-controlled trial of panax ginseng for cancer-related fatigue in patients with advanced cancer. J Natl Compr Canc Netw 2017; 15 (09) 1111-1120
- 45 Deutsche Gesellschaft für Kardiologie – Herz- und Kreislaufforschung. AWMF S3-Leitlinie Peri- und Postmenopause – Diagnostik und Interventionen. Im Internet. https://leitlinien.dgk.org/2020/s3-leitlinie-peri-und-postmenopause-diagnostik-und-interventionen/ Stand: 01.10.2023
- 46 Thamlikitkul L, Srimuninnimit V, Akewanlop C. et al Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin-cyclophosphamide regimen: A randomized, double-blind, placebo-controlled, crossover study. Support Care Cancer 2017; 25 (02) 459-464
- 47 Li QY, Cai FH, Lu Y. et al External treatment with Chinese herbal medicine for chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis. Front Pharmacol 2022; 13: 764473
- 48 Li SG, Chen HY, Ou-Yang CS. et al The efficacy of Chinese herbal medicine as an adjunctive therapy for advanced non-small cell lung cancer: A systematic review and meta-analysis. PLoS One 2013; 08 (02) e57604
- 49 Sun K, Wu L, Wang S. et al Antitumor effects of Chinese herbal medicine compounds and their nano-formulations on regulating the immune system microenvironment. Front Oncol 2022; 12: 949332
- 50 Zhao W, Zheng X DI, Tang PYZ. et al Advances of antitumor drug discovery in traditional Chinese medicine and natural active products by using multi-active components combination. Med Res Rev 2023; 43 (05) 1778-1808
- 51 Tao WW, Jiang H, Tao XM. et al Effects of acupuncture, tuina, tai chi, qigong, and traditional Chinese medicine five-element music therapy on symptom management and quality of life for cancer patients: A meta-analysis. J Pain Symptom Manage 2016; 51 (04) 728-747
- 52 Wang C, Liu H. Shen, et al Effects of tuina combined with moxibustion on breast cancer-related lymphedema: A randomized cross-over controlled trial. Integr Cancer Ther. 2023: 22
- 53 Li X, Wang X, Song L. et al Effects of qigong, tai chi, acupuncture, and tuina on cancer-related fatigue for breast cancer patients: A protocol of systematic review and meta-analysis. Medicine (Baltimore). 2020; Nov 11 99 (45) E23016
- 54 Wayne PM, Lee MS, Novakowski Jet al. Tai chi and qigong for cancer-related symptoms and quality of life: A systematic review and meta-analysis. J Cancer Surviv 2018; 12 (02) 256-267
- 55 Irwin MR, Olmstead R, Carrillo C. et al Tai chi compared with cognitive behavioral therapy for the treatment of insomnia in survivors of breast cancer: A randomized, partially blinded, noninferiority trial. J Clin Oncol 2017; 35 (23) 2656
- 56 Hilfiker R, Meichtry A, Eicher M. et al Exercise and other non-pharmaceutical interventions for cancer-related fatigue in patients during or after cancer treatment: A systematic review incorporating an indirect-comparisons meta-analysis. Br J Sports Med 2018; 52 (10) 651-658
- 57 Zhang YP, Hu RX, Han M. et al Evidence base of clinical studies on qi gong: A bibliometric analysis. Complement Ther Med 2020: 50-102392
- 58 Altman DG, Bland JM. Statistics notes: Absence of evidence is not evidence of absence. BMJ 1995; 311 7003 485