Synthesis, Table of Contents Synthesis 2023; 55(23): 4000-4010DOI: 10.1055/a-2147-2788 paper Application of the Heck Reaction for the Synthesis of C-Glycosyl Phenolic Compounds Sara M. Tomé a LAQV-REQUIMTE & Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal , Raquel G. Soengas ∗ b Department of Organic and Inorganic Chemistry, University of Oviedo, 33006 Oviedo, Spain , Artur M. S. Silva ∗ a LAQV-REQUIMTE & Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal› Author AffiliationsRecommend Article Abstract Buy Article All articles of this category Abstract The potential of the Heck reaction for the C-glycosylation of phenolic compounds was explored. An efficient and general methodology for the synthesis of C-glycosylated phenolic compounds based on the Heck coupling of halogenated phenolic derivatives (chromones, 2-styrylchromones, and xanthones) and sugar alkenes was developed. The protocol was applied to the preparation of previously unreported C-glycosylated 2-styrylchromones and xanthones of potential biological relevance. Key words Key wordsHeck reaction - phenolic compounds - chromones - xanthones - 2-styrylchromones - C-glycosylation Full Text References References 1a Quideau S, Deffieux D, Douat-Casassus C, Pouységu L. Angew. Chem. Int. Ed. 2011; 50: 586 1b Whiting DA. Nat. Prod. Rep. 2001; 18: 583 2 Bruneton J. Pharmacognosy – Phytochemistry Medicinal Plants, 2nd ed. Lavoisier Publishing; Paris: 1999 3 Ji Y, Li B, Qiao M, Li J, Xu H, Zhang L, Zhang X. Appl. Microbiol. Biotechnol. 2020; 104: 6587 4 Yang B, Liu H, Yang J, Gupta VK, Jiang Y. Trends Food Sci. Technol. 2018; 79: 116 5 Plaza M, Pozzo T, Liu J, Gulshan Ara KZ, Turner C, Nordberg Karlsson E. J. Agric. Food Chem. 2014; 62: 3321 6 Xiao J. Crit. Rev. Food Sci. Nutr. 2017; 57: 1874 7 Godinho PI. C, Soengas RG, Silva VL. M. Pharmaceuticals 2021; 14: 546 8a Rauter AP, Lopes RG, Martins A. Nat. 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