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Synthesis 2023; 55(19): 3204-3208
DOI: 10.1055/a-2114-7673
DOI: 10.1055/a-2114-7673
paper
A New One-Pot Synthesis of 3,6-Disubstituted Pyridazines Starting from β-Nitro-β,γ-Unsaturated Ketones
Authors
We gratefully acknowledge financial support from the University of Camerino and MIUR (PON Ricerca e Innovazione 2014-2020; PRIN 2017, NATURECHEM project grant n.2017A5HXFC).
Abstract
A new one-pot preparation of 3,6-disubstituted pyridazines starting from β-nitro-β,γ-unsaturated ketones and hydrazine monohydrate is presented. The protocol entails two sequential steps, leading to the isolation of the title targets in satisfactory overall yields tolerating a good variety of additional functionalities.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2114-7673.
- Supporting Information (PDF)
Publication History
Received: 24 May 2023
Accepted after revision: 21 June 2023
Accepted Manuscript online:
21 June 2023
Article published online:
31 July 2023
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