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Synthesis 2023; 55(14): 2253-2260
DOI: 10.1055/a-2042-3533
DOI: 10.1055/a-2042-3533
paper
Special Issue Honoring Prof. Guoqiang Lin’s Contributions to Organic Chemistry
One-Pot Iron-Catalyzed Cross-Coupling Reactions of Aryl Chlorides and Aryl Bromides
This work was supported by grants from the National Natural Science Foundation of China (NSFC) (22271243, 21971219), Guangdong Innovative and Entrepreneurial Research Team Program, Leading Talents Program of Guangdong Province, Shenzhen Science and Technology Innovation Committee for the Shenzhen Key Laboratory Fund, Research Grants Council (Hong Kong) (GRF CUHK14304819), and Innovation and Technology Commission (Hong Kong) in the form of a subsidy to the State Key Laboratory of Synthetic Chemistry, and by University Development Fund Grants from The Chinese University of Hong Kong, Shenzhen.
Abstract
A one-pot iron-catalyzed cross-coupling protocol involving aryl chlorides, aryl bromides and magnesium metal was developed towards the construction of unsymmetrical biaryls. The key procedure of this reaction is the in situ generation of Grignard reagents.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2042-3533.
- Supporting Information
Publication History
Received: 01 February 2023
Accepted after revision: 24 February 2023
Accepted Manuscript online:
24 February 2023
Article published online:
06 April 2023
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