PDF icon Download PDF
Am J Perinatol 2023; 40(09): 923-928
DOI: 10.1055/a-2011-8369
SMFM Fellowship Series Article

Term Neonatal Outcomes after Maternal Magnesium Sulfate Treatment for Seizure Prophylaxis

Rebecca Chornock
1   Division of Maternal-Fetal Medicine, Department of Women's and Infant's Services, MedStar Washington Hospital Center, Washington, District of Columbia
,
Elissa Trieu
1   Division of Maternal-Fetal Medicine, Department of Women's and Infant's Services, MedStar Washington Hospital Center, Washington, District of Columbia
,
Tetsuya Kawakita 
2   Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, Virginia
,
Brynley Dean
3   Georgetown University School of Medicine, Washington, District of Columbia
,
Rachael Overcash
1   Division of Maternal-Fetal Medicine, Department of Women's and Infant's Services, MedStar Washington Hospital Center, Washington, District of Columbia
› Author Affiliations
Funding None.
› Further Information
Also available ateRefHebammen
   Permissions and Reprints
Preview

Abstract

Objective This study aimed to evaluate term neonatal outcomes after maternal magnesium sulfate (MgSO4) treatment for seizure prophylaxis.

Study Design This was a single-site retrospective cohort study of all women with term singleton gestation requiring MgSO4 treatment for seizure prophylaxis and their respective neonatal outcomes from January 2013 through December 2020. Our primary outcome was neonatal intensive care unit (NICU) admission. We compared outcomes between women treated with MgSO4 for 24 hours or more and women treated with MgSO4 for less than 24 hours prior to delivery. Multivariable logistic regression was performed to calculate adjusted odds ratio (aOR) and 95% confidence interval (95% CI), controlling for variables with a p < 0.05 based on bivariable analysis.

Results Of 834 women analyzed, 173 (20.7%) neonates were admitted to the NICU. Women treated with MgSO4 for 24 hours or more compared with women treated with MgSO4 for less than 24 hours were more likely to have neonates admitted to the NICU during their hospitalization (27.3 vs. 18.9%; p = 0.01), neonates requiring immediate NICU admission (24.6 vs. 18.3%; p < 0.01), and NICU admission for neonatal lethargy. After adjusting for covariates, only NICU admission due to neonatal lethargy remained statistically significant (aOR: 4.78 [95% CI: 1.50–15.21]).

Conclusion Prolonged MgSO4 treatment for 24 hours or more was associated with increased odds of term NICU admission due to neonatal lethargy.

Key Points

  • NICU admission rose with longer magnesium treatment.

  • Nulliparous patients had more magnesium sulfate exposure.

  • Obese patients had longer magnesium sulfate exposure.

Keywords

magnesium sulfate - term neonate - preeclampsia - NICU

Note

This research was presented as a poster presentation at the ACOG Annual Clinical and Scientific Meeting, Washington, DC (April 30–May 3, 2021).




Publication History

Received: 20 October 2022

Accepted: 03 January 2023

Accepted Manuscript online:
12 January 2023

Article published online:
21 February 2023

© 2023. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA