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Synthesis 2023; 55(03): 481-488
DOI: 10.1055/a-1954-4920
paper

Rhodium(III)-Catalyzed Intramolecular Benzylic C(sp3)–H Amidation for the Synthesis of Isoindolinones

Darun Yang
,
Hongyan Xu
,
Decai Huang
,
Huaiqing Zhao∗
This work was supported by the Shandong Provincial Natural Science Foundation, China (ZR2020MB006 and ZR2016JL009) and the University of Jinan.
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Abstract

The synthesis of N-unprotected isoindolinones via rhodium(III)-catalyzed intramolecular C(sp3)–H amidation of various 2-methyl-N-substituted benzamides is developed. This protocol employs a free amino acid l-alanine as a ligand, which could significantly increase the reactivity of rhodium catalyst.

Key words

rhodium(III) catalyst - C(sp3)–H amidation - isoindolinones - N-substituted benzamides - synthetic methods

Supporting Information

    Supporting information for this article is available online at https://doi.org/10.1055/a-1954-4920.
  • Supporting Information


Publikationsverlauf

Eingereicht: 23. August 2022

Angenommen nach Revision: 04. Oktober 2022

Accepted Manuscript online:
04. Oktober 2022

Artikel online veröffentlicht:
10. November 2022

© 2022. Thieme. All rights reserved

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