A New Avenue to One-Pot Four-Component Synthesis of Spiro[indoline-3,4′-quinoline] Derivatives Using DABCO as a Green Catalyst

Abstract

A simple, efficient, and green, one-pot four-component synthesis of spiro[indoline-3,4′-quinoline] derivatives has been developed from isatin, ethyl cyanoacetate/malononitrile, dimedone, and aniline using green catalyst DABCO and green solvent ethanol. The current method generates good to exceptional yields in a short reaction time and provides a broad substrate scope. This method also works for gram-scale reactions.

Keywords

DABCO - spiro[indoline-3,4′-quinoline] derivatives - isatin - ethyl cyanoacetate - malononitrile - dimedone - anilines

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