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Am J Perinatol 2022; 39(15): 1614-1621
DOI: 10.1055/a-1877-8617
SMFM Fellowship Series Article

Resolved but Not Forgotten: The Effect of Resolved Placenta Previa on Labor Management

Kristina M. Feldman 
1   Division of Maternal-Fetal Medicine, Obstetrics, Gynecology and Reproductive Medicine, Icahn School of Medicine at Mount Sinai, Mount Sinai West, New York, New York
,
Andre Robinson
2   Obstetrics, Gynecology and Reproductive Medicine, Icahn School of Medicine at Mount Sinai, Mount Sinai West, New York, New York
,
Caroline Gellman
2   Obstetrics, Gynecology and Reproductive Medicine, Icahn School of Medicine at Mount Sinai, Mount Sinai West, New York, New York
,
Elianna Kaplowitz
3   Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York
,
Farrah N. Hussain 
1   Division of Maternal-Fetal Medicine, Obstetrics, Gynecology and Reproductive Medicine, Icahn School of Medicine at Mount Sinai, Mount Sinai West, New York, New York
,
Zainab AL-Ibraheemi
1   Division of Maternal-Fetal Medicine, Obstetrics, Gynecology and Reproductive Medicine, Icahn School of Medicine at Mount Sinai, Mount Sinai West, New York, New York
,
Tirtza S. Strauss
1   Division of Maternal-Fetal Medicine, Obstetrics, Gynecology and Reproductive Medicine, Icahn School of Medicine at Mount Sinai, Mount Sinai West, New York, New York
,
Graham Ashmead
1   Division of Maternal-Fetal Medicine, Obstetrics, Gynecology and Reproductive Medicine, Icahn School of Medicine at Mount Sinai, Mount Sinai West, New York, New York
,
David Cole
1   Division of Maternal-Fetal Medicine, Obstetrics, Gynecology and Reproductive Medicine, Icahn School of Medicine at Mount Sinai, Mount Sinai West, New York, New York
,
Lois Brustman
1   Division of Maternal-Fetal Medicine, Obstetrics, Gynecology and Reproductive Medicine, Icahn School of Medicine at Mount Sinai, Mount Sinai West, New York, New York
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Abstract

Objectives Placenta previa is diagnosed in up to 15% of pregnancies at the anatomy ultrasound and 0.5% persist to term. There is limited data regarding pregnancy outcomes with resolved previa. We aimed to examine patients with resolved placenta previa to determine if abnormal placentation at any time during pregnancy is associated with adverse events during labor.

Study Design Patients with placenta previa were identified after second trimester ultrasound, included if placenta previa resolved with the placental edge greater than 2 cm from the internal cervical os, and excluded if placenta previa persisted to term, resolution occurred prior to 20 weeks, patients underwent a prior cesarean delivery, or delivered at an outside institution. Time-matched controls were identified among patients with normal placental location. Demographic data and outcomes were collected. Student's t-test, Wilcoxon's rank-sum test, Chi-square, Fisher's exact test, and univariable and multivariable logistic regression were used as appropriate

Results Overall, 560 patients had placenta previa, 275 had resolved placenta previa, 285 were excluded. Resolved placenta previa patients were significantly older with lower prepregnancy body mass index (BMI), were significantly more likely to be a current smoker, have used assisted reproductive technology, and have had previous uterine surgeries. Overall, 10.2% of patients with resolved placenta previa experienced postpartum hemorrhage, compared with 2.1% in the normal placentation group. Patients with resolved placenta previa were 5.2 times more likely to have a postpartum hemorrhage (odds ratio [OR] = 5.2, 95% confidence interval [CI]: 2.1–12.7; p < 0.01) and 3.4 times more likely to require extra uterotonic medications (OR = 3.4, 95% CI: 1.9–6.2; p < 0.01). There is no difference with regard to rates of operative delivery for fetal distress (OR = 1.2, 95% CI: 0.7–1.9; p = 0.48), or category-II or-III fetal heart tracing around the time of delivery.

Conclusion Patients with resolved placenta previa had a higher rate of postpartum hemorrhage and use of uterotonic agents. This information might have important clinical implications and could be incorporated into the hemorrhage risk assessment during labor.

Key Points

  • This study aimed to determine if patients with resolved placenta previa had an increased risk of expedited delivery due to fetal distress during labor.

  • Patients age with resolved placenta previa have similar risk factors to those with persistent placenta previa, including older maternal, lower prepregnancy BMI, current smoking status, use of assisted reproductive technology (ART) and history of previous uterine surgeries. They were not at increased risk for operative vaginal delivery or cesarean section due to fetal distress. They did require increased uterotonic use and were at an increased risk for postpartum hemorrhage

  • Patients with resolved placenta previa should undergo hemorrhage precautions at the time of admission.

Keywords

placenta previa - resolved placenta previa - anatomy ultrasound - postpartum hemorrhage - uterotonic medication - fetal distress - expedited delivery

Note

The findings were presented in SMFM 2021 41st Annual Pregnancy Meeting for Poster Presentation (submission ID: 945948, program ID: 556) January 25–30, 2021 in Las Vegas, NV.




Publication History

Received: 16 August 2021

Accepted: 03 June 2022

Accepted Manuscript online:
16 June 2022

Article published online:
25 August 2022

© 2022. Thieme. All rights reserved.

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