Pharmacopsychiatry 2022; 55(06): 291-296
DOI: 10.1055/a-1860-2793
Original Paper

Aripiprazole Once-Monthly Versus Oral Aripiprazole for Schizophrenia in the Maintenance Phase: A Systematic Review and Network Meta-Analysis

Taro Kishi
1   Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
,
Kenji Sakuma
1   Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
,
Nakao Iwata
1   Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
› Author Affiliations

Abstract

IntroductionTo examine whether aripiprazole once-monthly (AOM) was more beneficial than oral aripiprazole (OARI) in the treatment of adults with schizophrenia during the maintenance phase.

MethodsWe performed a systematic review and network meta-analysis of double-blind, randomized controlled trials that included two of the following treatments: AOM, OARI, and placebo.

ResultsWe identified four studies involving 1830 adults. Relapse rates at 26 weeks were lower for both AOM (odds ratio [OR] 0.240, 95% confidence interval [CI] 0.169–0.341) and OARI (OR=0.306, 95%CI=0.217–0.431) than for placebo, although their treatment outcomes did not differ significantly (OR=0.786, 95%CI=0.529–1.168). Rates of all-cause discontinuation were also lower with AOM (OR=0.300, 95% CI=0.227–0.396) and OARI (OR=0.441, 95%CI=0.333–0.582) than with placebo. The rate of all-cause discontinuation was lower with AOM than with OARI (OR=0.681, 95% CI=0.529–0.877)]. Other outcomes did not differ significantly between AOM and OARI.

DiscussionAlthough both AOM and OARI were efficacious in the treatment of schizophrenia during the maintenance phase, AOM was better accepted than OARI.

Supplementary Material



Publication History

Received: 23 March 2022
Received: 29 April 2022

Accepted: 07 May 2022

Article published online:
05 July 2022

© 2022. Thieme. All rights reserved.

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Rüdigerstraße 14, 70469 Stuttgart, Germany

 
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