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Synthesis 2022; 54(14): 3289-3297
DOI: 10.1055/a-1794-1314
DOI: 10.1055/a-1794-1314
paper
Cobalt(III)-Catalyzed C–H Activation/Annulation Cascade Reaction of N-Chlorobenzamides with 2-Acetylenic Ketones at Room Temperature
Authors
We are grateful for the support from Sichuan Science and Technology Program (No: 2020YJ0221; 2018JY0537).
Abstract
A mild cascade annulation of Co(III)-catalyzed N-chlorobenzamides with 2-acetylenic ketones at room temperature is reported. This reaction sets N–Cl bond of N-chlorobenzamide as an internal oxidant, displaying broad functional group tolerance and excellent reverse selectivity of alkyne insertion under mild and safe conditions. The cascade reaction offers a straightforward and mild protocol to construct isoquinolones in high yields at room temperature.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1794-1314.
- Supporting Information (PDF)
Publication History
Received: 25 February 2022
Accepted after revision: 10 March 2022
Accepted Manuscript online:
10 March 2022
Article published online:
03 May 2022
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