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Synthesis 2022; 54(11): 2696-2706
DOI: 10.1055/a-1737-2765
DOI: 10.1055/a-1737-2765
paper
Radical Addition of 4-Hydroxyquinazolines and Alkylation of Quinones by the Electro-Induced Homolysis of 4-Alkyl-1,4-dihydropyridines
Authors
Financial support was received from National Natural Science Foundation of China (21907064, 22077080, and 22107068).
Abstract
The formation of C(sp3)-centered radicals via the electro-induced homolysis of 4-alkyl-1,4-dihydropyridines (alkyl-DHPs) is reported. The resulting alkyl radicals reacted with 4-hydroxyquinazolines or quinones to afford 2-alkyldihydroquinazolinones or alkylated quinones. A broad range of alkyl DHPs could be used as versatile radical precursors under electrolysis conditions. This alterative strategy provided a simple and effective pathway for the construction of C(sp2)–C(sp3) and C(sp3)–C(sp3) bonds under mild conditions.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1737-2765.
- Supporting Information (PDF)
Publication History
Received: 06 December 2021
Accepted after revision: 11 January 2022
Accepted Manuscript online:
11 January 2022
Article published online:
04 March 2022
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