Long Covid: Ursachen sprechen für den therapeutischen Einsatz von Antioxidantien

Zusammenfassung

Hyperinflammation und oxidativer Stress spielen nicht nur bei akuter Covid-19-Erkrankung, sondern auch bei Long Covid eine wichtige pathophysiologische Rolle. Bei Covid-19 wurde ein Vitamin-C-Mangel nachgewiesen und der Benefit von supportiven Vitamin-C-Infusionen bereits untersucht. Bei Long Covid sind die überschießende Entzündung und reaktive Sauerstoffverbindungen ebenfalls Mitauslöser für Fibrosen, Thrombosen, Immun-Dysregulation (Autoimmunphänomene und Virenpersistenz), Fatigue, kognitive Beeinträchtigungen und Störungen des autonomen Nervensystems. Der Benefit von Vitamin-C-Infusionen – wie die Linderung von Fatigue, kognitiven Störungen und Schmerzen – ist bereits bei anderen Grunderkrankungen gut untersucht. Vitamin C ist eines der effektivsten Antioxidantien, Kofaktor relevanter Stoffwechselwege und ein wichtiger Immunmodulator. Der therapeutische Einsatz bei Long Covid ist deshalb sehr plausibel und wird durch praktische Erfahrung bestätigt.

Abstract

Hyperinflammation and oxidative stress play an important pathophysiological role not only in acute COVID-19 disease but also in Long-COVID. In COVID-19, vitamin C deficiency has been demonstrated and the benefit of supportive vitamin C infusions has already been investigated. In Long-COVID, excessive inflammation and reactive oxygen species are co-triggers for fibrosis, thrombosis, immune dysregulation (autoimmune phenomena and viral persistence), fatigue, cognitive impairment and autonomic nervous system dysfunction. The benefits of vitamin C infusions – such as alleviation of fatigue, cognitive impairment and pain – have already been widely studied in other underlying diseases. Vitamin C is one of the most effective antioxidants, co-factor of relevant metabolic pathways and an important immune modulator. The therapeutic use in Long-COVID is therefore very plausible and is confirmed by practical experience.

Schlüsselwörter

Long Covid - Post-Covid-19-Syndrom - Vitamin C - Immunmodulation - oxidativer Stress - Antioxidantien

Keywords

Long COVID - post COVID-19 syndrome - vitamin C - immune modulation - oxidative stress - antioxidants

Publication History

Article published online:
12 October 2022

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