Synthesis 2022; 54(05): 1347-1352
DOI: 10.1055/a-1668-9910
paper

Synthesis of Bis(indolyl)methanes through an Alkylation Reaction of Indoles with Sodium Alkoxides

Authors


We thank the National Natural Science Foundation of China (Nos. 22001231 and 21772176) and the Natural Science Foundation of Zhejiang­ Province (Nos. LQ20B020012 and LY20B020013) for financial support.


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Abstract

We describe an alkylation reaction of indoles with sodium alkoxides for the synthesis of bis(indolyl)methanes. 1-Tetralone proved to be an efficient hydrogen acceptor, thus avoiding the use of precious transition metals such as Ru and Ir. This reaction features transition-metal-free conditions, uses readily available starting materials, and can be conducted on a gram scale.

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Publication History

Received: 14 September 2021

Accepted after revision: 14 October 2021

Accepted Manuscript online:
14 October 2021

Article published online:
18 November 2021

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