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Synthesis 2021; 53(21): 4117-4123
DOI: 10.1055/a-1534-0466
DOI: 10.1055/a-1534-0466
paper
Elemental Sulfur Mediated Synthesis of Pyrrolo[1,2-a]quinoxalines from 1-(2-Nitroaryl)pyrroles
We thank the Viet Nam National University Ho Chi Minh City (VNU-HCM) for financial support via project no. NCM2019-20-01 (for N.T.S.P.).
Abstract
Methods to afford pyrrolo[1,2-a]quinoxalines often require the use of prefunctionalized aniline precursors, transition metals, and/or harsh conditions. Herein we describe a simple coupling of 1-(2-nitroaryl)pyrroles and arylacetic acids, in the presence of elemental sulfur, to furnish the fused heterocycles in good yields. The conditions are compatible with many functionalities including ester, nitrile, halogen, and nitro groups. Use of benzyl alcohols and picoline coupling reagents was also attempted.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1534-0466.
- Supporting Information
Publication History
Received: 21 May 2021
Accepted after revision: 22 June 2021
Accepted Manuscript online:
22 June 2021
Article published online:
22 July 2021
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