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Synthesis 2021; 53(15): 2643-2650
DOI: 10.1055/a-1464-2473
paper

A Convenient Protecting Group for Uridine Ureido Nitrogen: (4,4′-Bisfluorophenyl)methoxymethyl Group

Katsuhiko Mitachi
,
David Mingle
,
Michio Kurosu  ∗
Research reported in this publication was supported by the National Institute of General Medical Sciences of the National Institutes of Health under award number R01GM114611. M.K. thanks UTRF (University of Tennessee Health Science Center) for generous financial support (Innovation award R079700292).
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Abstract

(4,4′-Bisfluorophenyl)methoxymethyl (BFPM) group of uridine ureido nitrogen shows good relative stability in a variety of chemical transformation reactions for uridine. The BFPM group can be cleaved by 2% of TFA in CH2Cl2 without affecting the Boc group.

Key words

uridine - ureido nitrogen - diarylmethoxymethyl group - [bis(4-fluorophenyl)methoxy]methyl group - chemical transformations - muraymycin synthesis

Supporting Information

    Supporting information for this article is available online at https://doi.org/10.1055/a-1464-2473.
  • Supporting Information


Publication History

Received: 14 December 2020

Accepted after revision: 25 March 2021

Accepted Manuscript online:
25 March 2021

Article published online:
12 April 2021

© 2021. Thieme. All rights reserved

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