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Synthesis 2021; 53(13): 2286-2292
DOI: 10.1055/a-1375-3538
DOI: 10.1055/a-1375-3538
paper
Synthesis of Difluoromethyl-Substituted Quinazolines through Selective Difluoromethylation
Financial support from National Natural Science Foundation of China (nos: 21502188, 21362014, 21762020), Jiangxi Provincial Department of Science and Technology (no. 20171BAB203006), and Key Laboratory of Functional Small Organic Molecules, Ministry of Education, Jiangxi Normal University (no. KLFS-KF-201702) is gratefully acknowledged.
Abstract
A highly selective difluoromethylation of quinazolines has been achieved by using commercially available ethyl bromodifluoroacetate as difluorocarbene precursor, providing the corresponding difluoromethyl substituted quinazoline derivatives with up to 83% yield.
Key words
difluoromethylation - quinazoline - ethyl bromodifluoroacetate - difluoromethyl substituted quinazoline - difluorocarbeneSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1375-3538.
- Supporting Information
Publikationsverlauf
Eingereicht: 26. Dezember 2020
Angenommen nach Revision: 27. Januar 2021
Accepted Manuscript online:
27. Januar 2021
Artikel online veröffentlicht:
22. Februar 2021
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