Depressive Störungen: Eine oft unterschätzte Komorbidität bei Diabetes

Bei Menschen mit Diabetes liegt oft neben dem Diabetes auch eine depressive Störung vor, die die Therapie erschwert und die Prognose der Erkrankung verschlechtert. Depressionen stellen im Kontext der Diabeteserkrankung einen häufig unterschätzten Risikofaktor dar. Ziel dieses Beitrags ist es, die Bedeutung der Depression bei Diabetes für den Verlauf der Erkrankung zu erörtern und einen Überblick über die wichtigsten diagnostischen und therapeutischen Empfehlungen für die Praxis zu geben.

Abstract

People with diabetes often have a depressive disorder in addition to diabetes, which makes therapy more difficult and worsens the prognosis of the disease. Depression is an often underestimated risk factor in the context of diabetes. The aim of this article is to illustrate the significance of depression in diabetes for the course of the disease and to provide an overview of the most important diagnostic and therapeutic recommendations for practice.

Schlüsselwörter

depressive Störung - Stoffwechselstörung - Komorbidität - psychiatrische Begleiterkrankung

Key words

depressive disorder - metabolic disorder - comorbidity - concomitant psychiatric disease

Publication History

Article published online:
03 November 2020

• Literatur

• 1 Kulzer B, Albus C, Herpertz S. et al Psychosoziales und Diabetes. S2-Leitlinie. Teil 1. Diabetologie und Stoffwechsel 2013; 8 (03) 198-242 . doi:10.1055/s-0033-1335785
• 2 Yu M, Zhang X, Lu F. et al Depression and risk for diabetes: a meta-analysis. Can J Diabetes 2015; 39 (04) 266-272 . doi:10.1016/j.jcjd.2014.11.006
• 3 Golden SH, Lazo M, Carnethon M. et al Examining a bidirectional association between depressive symptoms and diabetes. JAMA 2008; 299 (23) 2751-2759 . doi:10.1001/jama.299.23.2751
• 4 Sun JC, Xu M, Lu JL. et al Associations of depression with impaired glucose regulation, newly diagnosed diabetes and previously diagnosed diabetes in Chinese adults. Diabet Med 2015; 32 (07) 935-943 . doi:10.1111/dme.12649
• 5 Hermanns N, Ehrmann D, Kulzer B. How should we treat people with diabetes and comorbid depression?. J Diabetes Complic 2016; 30 (02) 187-188 . doi:10.1016/j.jdiacomp.2015.11.023
• 6 Ehrmann D, Kulzer B, Haak T. et al Longitudinal relationship of diabetes-related distress and depressive symptoms: analysing incidence and persistence. Diabet Med 2015; 32: 1264-1271 . doi:org/10.1007/s11428-017-0277-8
• 7 Hermanns N, Schmitt A, Gahr A. et al The effect of a Diabetes–Specific Cognitive Behavioral Treatment Program (DIAMOS) for patients with diabetes and subclinical depression: results of a randomized controlled trial. Diabetes Care 2015; 38 (04) 551-560 . doi:10.2337/dc14-1416
• 8 Egede LE. Diabetes, major depression, and functional disability among U.S. adults. Diabetes Care 2004; 27 (02) 421-428 . doi:10.2337/diacare.27.2.421
• 9 Sullivan MD. et al Depression predicts all-cause mortality: epidemiological evaluation from the ACCORD HRQL substudy. Diabetes care 2012; 35 (08) 1708-1715
• 10 Hofmann M, Köhler B, Leichsenring F. et al Depression as a risk factor for mortality in individuals with diabetes: a meta-analysis of prospective studies. PloS one 2013; 8 (11) e79809
• 11 Egede LE, Nietert PJ, Zheng D. Depression and all-cause and coronary heart disease mortality among adults with and without diabetes. Diabetes Care 2005; 28 (06) 1339-1345 . doi:10.2337/diacare.28.6.1339
• 12 Ho CS, Jin A, Nyunt MS. et al Mortality rates in major and subthreshold depression: 10-year follow-up of a Singaporean population cohort of older adults. Postgrad Med 2016; 128 (07) 642-647
• 13 Mutambudzi M, Chen NW, Markides KS. et al Effects of Functional Disability and Depressive Symptoms on Mortality in Older Mexican-American Adults with Diabetes Mellitus. J Am Geriatr Soc 2016; 64 (11) e154-e159
• 14 Downer B, Rote S, Markides KS. et al The Comorbid Influence of High Depressive Symptoms and Diabetes on Mortality and Disability in Mexican Americans Aged 75 and Above. Gerontol Geriatr Med 2016 2.
• 15 Deutsche Gesellschaft für Psychiatrie, Psychotherapie und Nervenheilkunde, Bundesärztekammer, Kassenärztliche Bundesvereinigung al. S3-Leitlinie/Nationale VersorgungsLeitlinie: unipolare Depression; Langfassung; Version 5 [online]: 06.2015. Im Internet (Stand: 29.09.2020): https://www.awmf.org/uploads/tx_szleitlinien/nvl-005l_S3_Unipolare_Depression_2017-05.pdf
• 16 Roopan S, Larsen ER. Use of antidepressants in patients with depression and comorbid diabetes mellitus: a systematic review. Acta Neuropsychiatr 2017; 29 (03) 127-139 . doi:10.1017/neu.2016.54
• 17 Atlantis E, Fahey P, Foster J. Collaborative care for comorbid depression and diabetes: a systematic review and meta-analysis. BMJ Open 2014; 4 (04) e004706 . Published 2014 Apr 12. doi:10.1136/bmjopen-2013–004706
• 18 Bogner HR, Morales KH, Post EP. et al Diabetes, depression, and death: a randomized controlled trial of a depression treatment program for older adults based in primary care (PROSPECT). Diabetes Care 2007; 30 (12) 3005-3010 . doi:10.2337/dc07-0974