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Homeopathy 2015; 104(02): 90-96
DOI: 10.1016/j.homp.2015.01.002
 
Copyright © The Faculty of Homeopathy 2015

Hormesis within a mechanistic context

Edward J. Calabrese
Subject Editor:
Further Information

Publication History

Received22 August 2014
revised19 November 2014

accepted26 January 2015

Publication Date:
19 December 2017 (online)

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This paper provides an assessment of the mechanistic foundations of hormesis and how such understandings evolved over the course of the past century. Particular emphasis is placed on recent developments particularly with respect to receptor-based and cell signaling-based pathways. Of particular importance is that the quantitative feature of the hormetic dose response are independent of mechanism.

Keywords

Hormesis - Dose–response - Biphasic - U-shaped - Adaptive response
 

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