Time Varying Neonatal Seizure Localization

W. Deburchgraeve; P. J. Cherian; M. De Vos; R. M. Swarte; J. H. Blok; G. H. Visser; P. Govaert; S. Van Huffel

doi:10.3414/ME09-02-0041

Methods of Information in Medicine, Table of Contents

Methods Inf Med 2010; 49(05): 473-478
DOI: 10.3414/ME09-02-0041

Special Topic – Original Articles

Schattauer GmbH

Time Varying Neonatal Seizure Localization

Authors

W. Deburchgraeve

¹Department of Electrical Engineering (ESAT), Katholieke Universiteit Leuven, Leuven-Heverlee, Belgium
P. J. Cherian

²Department of Clinical Neurophysiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
M. De Vos

¹Department of Electrical Engineering (ESAT), Katholieke Universiteit Leuven, Leuven-Heverlee, Belgium
R. M. Swarte

³Department of Neonatology, Sophia Children’s Hospital, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
J. H. Blok

²Department of Clinical Neurophysiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
G. H. Visser

²Department of Clinical Neurophysiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
P. Govaert

³Department of Neonatology, Sophia Children’s Hospital, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
S. Van Huffel

¹Department of Electrical Engineering (ESAT), Katholieke Universiteit Leuven, Leuven-Heverlee, Belgium

Abstract

Summary

Background: A common cause for damage to the neonatal brain is a shortage in the oxygen supply to the brain or asphyxia. Neonatal seizures are the most frequent manifestation of neonatal neurologic disorders. Multichannel EEG recordings allow topographic localization of seizure foci.

Objectives: We want to objectively determine the spatial distribution of the seizure on the scalp, the location in time and order the dominant sources in the brain based on their strength.

Methods: In this paper we combine a method based on higher order CP-decomposition with subsequent singular value decomposition (SVD).

Results: We illustrate the abilities of the method on simulated as well as on real neonatal seizure EEG.

Conclusions: The proposed method provides reliable time and spatial information about the seizure, gives a clear overview of what is going on in the EEG and allows easy interpretation.

Keywords

CP-decomposition - neonatal EEG - seizure localization

Full Text

References

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