Synlett 2008(8): 1125-1128  
DOI: 10.1055/s-2008-1072717
LETTER
© Georg Thieme Verlag Stuttgart · New York

Microwave-Assisted Hydrogenation of Pyridines

Leonarda Pirasa, Eva Genesiob, Chiara Ghironb, Maurizio Taddei*aa Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via A. Moro, 53100 Siena, Italy
Fax: +39(0577)234333; e-Mail: taddei.m@unisi.it;
b Siena Biotech SpA, Via Fiorentina 1, 53100 Siena, Italy
Further Information

Publication History

Received 19 January 2008
Publication Date:
16 April 2008 (eFirst)

Abstract

Using a commercially available device for controlled introduction of hydrogen in a vial for reactions under microwave dielectric heating, we developed a protocol for the transformation of substituted pyridines into the corresponding piperidines. Complete reduction occurred in 40 minutes, or even less, on substrates that require 24-48 hours to be reduced under standard conditions. Moreover, the reduction proved to be as stereoselective as the corresponding reaction carried out at room temperature.