Microwave-Assisted Hydrogenation of Pyridines
16 April 2008 (eFirst)
Using a commercially available device for controlled introduction of hydrogen in a vial for reactions under microwave dielectric heating, we developed a protocol for the transformation of substituted pyridines into the corresponding piperidines. Complete reduction occurred in 40 minutes, or even less, on substrates that require 24-48 hours to be reduced under standard conditions. Moreover, the reduction proved to be as stereoselective as the corresponding reaction carried out at room temperature.
microwave - hydrogenation - piperidines - heterogeneous catalysis