Abstract
Pyrazino[2′,3′:4,5]thieno[3,2-d ]pyrimidine derivatives 6 were synthesized by the intermolecular aza-Wittig reaction of N -heteroaryl phosphazene derivatives with carboxylic acid chlorides. The heterocyclization occurs via imidoyl chloride intermediates derived from phosphazenes 4a ,b , obtained in a one-step process from α-azidothieno[2,3-b ]pyrazine carboxylic acid 3 . Moreover, cyclic pyrazinothienopyrimidines were prepared, in a two-step procedure, from amides and azidothienopyrazine-α-carbonyl chloride using an intramolecular aza-Wittig heterocyclization reaction strategy.
Key words
heterocycles - Wittig reaction - nitrogen - azides - cyclizations
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