Stereocontrolled Synthesis of Novel Spirocyclic Oxa-Bridged Cyclooctanoids through Sequential Transformations of Pentafulvenes

Abstract

A novel and efficient methodology for the stereocontrolled synthesis of spirocyclic oxa-bridged cyclooctanoids having multiple spiro centers is described. The cycloaddition reaction, which affords spirocyclic cyclooctanoids is highly sterospecific and has been supported by theoretical calculations.

Key words

pentafulvenes - oxidopyrylium betaines - oxa-bridged spirocycles - macromolecules

References

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Crystallographic data for 7a have been deposited with the Cambridge Crystallographic Data Center as supplementary publication number CCDC 644182. Copies of the data may be obtained, free of charge, on application to CCDC, 12 Union Road, Cambridge, CB2 1EZ, UK (fax: [phone] or e-mail: [e-mail]).