Synlett 2008(16): 2552-2553  
DOI: 10.1055/s-2008-1067119
SPOTLIGHT
© Georg Thieme Verlag Stuttgart ˙ New York

Urea: A Useful and Inexpensive Chemical for Organic Synthesis

Ricardo Antônio Wanderley Neves Filho*
Federal University of Pernambuco, 50740540, Recife, Pernambuco, Brazil
e-Mail: rawnf@yahoo.com.br;
Further Information

Publication History

Publication Date:
15 July 2008 (online)

Introduction

Urea was the first organic compound to be synthesized from inorganic reagents. This easily accessible chemical has been used as building block in the synthesis of N-carbamoyl-l-amino acids, [¹] cyclic carbonates, [²] and many ­nitrogen-containing heterocycles such as pyridines, [³] pyrimidines, [4] 3,4-dihydropyrimidinones, [5] oxazines, [6] 1,3-oxazin-3-ones, [7] and iminosugars. [8] Another application of urea in carbohydrate chemistry was described earlier. [9] Urea is also employed as source of ammonia in the syntheses of triarylamines, [¹0] imides, [¹¹] and amides. [¹²] Urea is an inexpensive, commercially available colorless crystalline compound, and is soluble in a large range of polar solvents including water. Its recent applications are given below.

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