Synlett 2008(8): 1267-1269  
DOI: 10.1055/s-2008-1066999
SPOTLIGHT
© Georg Thieme Verlag Stuttgart · New York

KX/H2O2 - An Efficient and Non-Polluting Halogenating Reagent in Organic Synthesis

Navath Suryakiran*
Organic Chemistry Division-I, Indian Institute of Chemical Technology (IICT), Hyderabad 500007, India
e-Mail: suryakiran.navath@gmail.com;
Further Information

Publication History

Publication Date:
16 April 2008 (online)

Introduction

Halogenated organic compounds have long been known as useful synthetic intermediates, which are not only man-made, but also synthesized by a large number of different organisms. [1] Halogenated organic compounds are important components in a variety of biologically active molecules and pharmaceutical agents. [2] They form an important class of intermediates as they can be converted efficiently into other functionalities by simple chemical transformations. For example aryl, vinyl and benzylic halides serve as important precursors to organolithium [3] and Grignard [4] reagents in C-C bond formation. Aryl halides have been employed as substrates for nucleophilic aromatic substitutions [5] and for benzyne generation. [6] Additionally, both aryl [7] [8] and vinyl [9] halides have found widespread utility as substrates for a variety of cross-coupling reactions. As a result of the diverse potential applications of organic halides, the development of new regioselective, chemoselective and functional-group tolerant approaches using non-polluting reagents for the synthesis of these molecules remains an important challenge. In this context, KX/H2O2 serves as an efficient and non-polluting halogenation reagent in organic synthesis.

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