Eur J Pediatr Surg 2009; 19(4): 265-267
DOI: 10.1055/s-2008-1039008
Case Gallery

© Georg Thieme Verlag KG Stuttgart · New York

Adrenocortical Adenoma Expressing Glucocorticoid in an 8-Month-Old Female

E. Kim1 , P. Aguayo2 , S. D. St. Peter2 , G. W. III  Holcomb2
  • 1Department of Pediatrics, Center for Prospective Trials, Children's Mercy Hospital, Kansas City, MO, USA
  • 2Department of Surgery, Center for Prospective Trials, Children's Mercy Hospital, Kansas City, MO, USA
Further Information

Publication History

Publication Date:
05 February 2009 (online)


Adrenocortical tumors are extremely rare in children. The annual worldwide incidence of adrenocortical tumors in children under 15 years of age has been estimated at 0.3 – 0.38 per million [8]. While only 25 cases of adrenocortical tumors occur annually in the United States in patients younger than 20 years of age [3], 65 % of them occur in children younger than 5 years of age [6]. We present here an unusual case of an infant presenting with a large, active adrenocortical tumor that was removed laparoscopically.


  • 1 Bugg M F, Ribeiro R C, Roberson P K. et al . Correlation of pathologic features with clinical outcome in pediatric adrenocortical neoplasia. A study of a Brazilian population. Brazilian Group for Treatment of Childhood Adrenocortical Tumors.  Am J Clin Pathol. 1994;  101 625-629
  • 2 Ciftci A O, Senocak M E, Tanyel F C. et al . Adrenocortical tumors in children.  J Pediatr Surg. 2001;  36 549-554
  • 3 Michalkiewicz E, Sandrini R, Figueiredo B. et al . Clinical and outcome characteristics of children with adrenocortical tumors: a report from the International Pediatric Adrenocortical Tumor Registry.  J Clin Oncol. 2004;  22 838-845
  • 4 Miller K A, Albanese C, Harrison M. et al . Experience with laparoscopic adrenalectomy in pediatric patients.  J Pediatr Surg. 2002;  37 979-982
  • 5 Ribeiro R C, Figueiredo B. Childhood adrenocortical tumours.  Eur J Cancer. 2004;  40 1117-1126
  • 6 Ribeiro R C, Sandrini R. Adrenocortical carcinoma in children: clinical aspects and prognosis.  J Pediatr Surg. 1994;  29 122
  • 7 Sbragia L, Oliveira-Filho A G, Vassallo J. et al . Adrenocortical tumors in Brazilian children: immunohistochemical markers and prognostic factors.  Arch Pathol Lab Med. 2005;  129 1127-1131
  • 8 Stiller C A. International variations in the incidence of childhood carcinomas.  Cancer Epidemiol Biomarkers Prev. 1994;  3 305-310

Dr., M.D. George W. Holcomb III

Department of Surgery
Center for Prospective Trials
Children's Mercy Hospital

2401 Gillham Road

Kansas City, MO 64108