Synlett 2008(6): 947-948  
DOI: 10.1055/s-2008-1032201
SPOTLIGHT
© Georg Thieme Verlag Stuttgart · New York

N-Bromosaccharin (NBSac)

Lokesh Kumar Pandey*
Synthetic Chemistry Division, Defence Research and Development, Establishment, Jhansi Road, Gwalior 474002, M.P., India.
e-Mail: lkp1976@gmail.com;
Further Information

Publication History

Publication Date:
11 March 2008 (online)

Introduction

N-Bromosaccharin (NBSac) is a strong oxidizing and chlorinating agent. It is a white powder, easy to handle, with its melting point at 160-170 °C. It is soluble in organic solvents, for example in alcohols, acetonitrile, tetrachloromethane, ethyl acetate, trichloromethane, acetone, and 1,4-dioxane. N-Bromosaccharin has been proven to be a useful and alternative reagent for diverse organic transformations, such as halogenation of aromatic compounds, co-halogenation of alkenes, oxidation of alcohols, halogenation of benzylic and carbonylic positions, etc. N-Bromosaccharin [1] can easily be prepared by bromination of the sodium salt of saccharin which is commonly available, non-corrosive, and non-toxic.

Figure 1

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