Synthesis 2008(4): 537-542  
DOI: 10.1055/s-2008-1032142
© Georg Thieme Verlag Stuttgart · New York

Trans-Spanned Palladium Catalyst for Mild and Efficient Amination of Aryl Halides with Benzophenone Imine

Olga Grossmana, Karola Rueck-Braunb, Dmitri Gelman*a
a Department of Organic Chemistry, The Hebrew University of Jerusalem, Givat Ram, 91904 Jerusalem, Israel
b Technische Universität Berlin, Institut für Chemie, Straße des 17. Juni 135, 10623 Berlin, Germany
Further Information

Publication History

Received 30 September 2007
Publication Date:
31 January 2008 (online)


A new protocol for palladium-catalyzed Buchwald-Hartwig amination of aryl chlorides and bromides with benzophenone imine as ammonia surrogate is described. The suggested reaction conditions are mild and may therefore be applied to a variety of sensitive starting materials.