Synthesis of (Z)-2-[(Z)-3-Alkylideneisobenzofuran-1(3H)-ylidene]acetic Acid Derivatives by Sequential Coupling-Cyclization between 3-(2-Iodophenyl)-3-oxopropanoic Acid Derivatives and Terminal Alkynes

Abstract

3-(2-Iodophenyl)-3-oxopropanoic acid derivatives reacted efficiently with various terminal alkynes in the presence of catalytic amounts of dichlorobis(triphenylphosphine)palladium and copper(I) iodide and two molar amounts of triethylamine in N,N-dimethylformamide at room temperature to afford the corresponding (Z)-2-[(Z)-3-alkylideneisobenzofuran-1(3H)-ylidene]acetic acid derivatives in reasonable yields.

Key words

alkynes - coupling - furans - palladium - ring closure

References

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