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Synthesis 2008(3): 383-386
DOI: 10.1055/s-2008-1032022
DOI: 10.1055/s-2008-1032022
PAPER
© Georg Thieme Verlag Stuttgart · New YorkAn Enantioselective Formal Synthesis of (+)-(R)-α-Lipoic Acid by an l-Proline-Catalyzed Aldol Reaction
Further Information
Received
12 September 2007
Publication Date:
10 January 2008 (online)
Publication History
Publication Date:
10 January 2008 (online)

Abstract
An efficient, highly stereocontrolled formal synthesis of (+)-(R)-α-lipoic acid was achieved, which utilizes an l-proline-catalyzed highly enantio- and diastereoselective cross-aldol reaction as the key step.
Key words
aldehyde - aldol reaction - ketone - lipoic acid - proline
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