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Synfacts 2008(1): 0073-0073
DOI: 10.1055/s-2007-991428
DOI: 10.1055/s-2007-991428
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Palladium-Catalyzed Synthesis of Spirocyclic Cyclopentanes
B. M. Trost*, N. Cramer, S. M. Silverman
Stanford University, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
18. Dezember 2007 (online)
Significance
Described here is a very powerful method for construction of enantioenriched oxaindolic cyclopentanes which are present in a great number of alkaloids. Under mild conditions, low catalyst loading and using either ligands L1 or L2 both diastereomers (trans-1 and cis-2) can be obtained with good yields and excellent ee values.