Direct Synthesis of Substituted Pyrimidines and Quinazolines

Matthew D. Hill; Mohammad Movassaghi

doi:10.1055/s-2007-990932

PSP

Direct Synthesis of Substituted Pyrimidines and Quinazolines

Matthew D. Hill, Mohammad Movassaghi*
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Fax: +1(617)2521504; e-Mail: movassag@mit.edu;

Abstract

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Abstract

A variety of N-vinyl and N-aryl amides were converted in one step into the corresponding pyrimidine and quinazoline derivatives, respectively. Amide activation with trifluoromethanesulfonic anhydride in the presence of 2-chloropyridine followed by nitrile addition to the activated amide derivative and annulation provides the desired azaheterocycles.

Key words

amide - nitrile - pyrimidine - quinazoline - annulation

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References

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