Synthesis 2008(5): 820-822  
DOI: 10.1055/s-2007-990931
© Georg Thieme Verlag Stuttgart · New York

Preparation of 1,2-Dihydroisoquinolines by a Three-Component Reaction under Catalyst-Free Conditions

Kentaro Isoa, S. Salprima Yudhaa, Naoki Asao*a,b
a Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan
b Research and Analytical Center for Giant Molecules, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan
Fax: +81(22)7953899; e-Mail: [email protected];
Further Information

Publication History

Received 14 May 2007
Publication Date:
28 November 2007 (online)


A variety of 1,2-dihydroisoquinoline derivatives have been efficiently prepared by a three-component reaction using ortho-alkynylbenzaldehydes, primary amines, and pronucleophiles under mild catalyst-free conditions.


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