New Paracyclophane Phosphine for Highly Enantioselective Ruthenium-Catalyzed Hydrogenation of Prochiral Ketones

Abstract

The synthesis of a new paracyclophane phosphine is described. This ligand was highly efficient in the ruthenium-catalyzed asymmetric hydrogenation of various aromatic and heteroaromatic ketones.

Key words

paracyclophane - hydrogenation - ruthenium - ketones - P,P-ligands

References

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15

We used only the two diamines (R,R)-DPEN and (S,S)-DPEN; DPEN = 1,2-diphenylethylenediamine. Complex 6a was prepared by use of the (R,R)-amine, whereas the (S,S)-diamine was used for complex 6b.