Eur J Pediatr Surg 2007; 17(6): 382-386
DOI: 10.1055/s-2007-989219
Original Article

© Georg Thieme Verlag KG Stuttgart · New York

Compensatory Renal Growth in Children with Unilateral Renal Tumor Treated by Nephron-Sparing Surgery or Nephrectomy

F. Cozzi1 , A. Zani1 , A. Schiavetti2 , F. Morini1 , V. deGaetano1 , M. Matrunola3 , D. A. Cozzi1
  • 1Department of Pediatric Surgery Unit, University of Rome “La Sapienza”, Rome, Italy
  • 2Department of Pediatric Oncology Unit, University of Rome “La Sapienza”, Rome, Italy
  • 3Department of Pediatric Radiology Unit, University of Rome “La Sapienza”, Rome, Italy
Further Information

Publication History

received April 27, 2007

accepted May 23, 2007

Publication Date:
11 December 2007 (online)


Introduction: In children with an unilateral renal tumor, nephron-sparing surgery (NSS) results in a more adequate renal function adaptation compared to nephrectomy. In the present study, we investigated whether nephron-sparing surgery is followed by a different renal structure adaptation compared to nephrectomy. Methods: Sixteen patients with unilateral renal tumor treated by nephrectomy (Group 1) and 10 treated by nephron-sparing surgery (Group 2) were enrolled in the study. Kidney volume was estimated by ultrasonography, using the formula for a prolate ellipsoid. Kidney volume was adjusted to the patient's weight and kidney laterality and expressed as a percentage of the expected volume of two kidneys in a healthy child. Total kidney volume (TKV) corresponded to the volume of the contralateral kidney in Group 1 patients, and to the volume of contralateral kidney + kidney remnant in Group 2 patients. Renal function was evaluated by serum creatinine values adjusted for sex and age and expressed as standard deviation scores (SDS). Results: Group 2 patients presented with a greater indexed TKV compared to Group 1 patients, (97.4 ± 18.8 % vs. 77.0 ± 17.7 %; p = 0.005). Indexed TKV below the reference range for healthy controls with two kidneys was found in 4 of 10 Group 2 patients vs. 14 of 16 Group 1 patients (p = 0.017). In both patient groups, correlation analysis of indexed TKV and creatinine SDS showed a negative correlation (r = - 0.47; p = 0.01). Conclusion: In children with unilateral renal tumor, NSS is followed by a more adequate compensatory restoration of TKV compared with nephrectomy.


Prof. M.D. Francesco Cozzi

Department of Pediatric Surgery Unit
University of Rome “La Sapienza”

Viale Regina Elena 324

00161 Rome


Email: [email protected]