Synlett 2007(12): 1966-1968  
DOI: 10.1055/s-2007-984534
LETTER
© Georg Thieme Verlag Stuttgart · New York

Efficient Regio- and Stereoselective Synthesis of 1-β-O-Glucuronyl Carba­mates and Carbonates from Unprotected 1,2,3,4-Hydroxyl Glucuronates

Mickaël Thomas, Jean-Pierre Gesson, Sébastien Papot*Université de Poitiers, CNRS, Synthèse et Réactivité des Substances Naturelles, 40 Av. du Recteur Pineau, 86022 Poitiers, France
e-Mail: sebastien.papot@univ-poitiers.fr;
Further Information

Publication History

Received 17 April 2007
Publication Date:
27 June 2007 (eFirst)

Abstract

The coupling of either isocyanates or chloroformates with hydroxyl-unprotected glucuronates in the presence of N-methylmorpholine allowed the preparation of a range of 1-β-O-glucuronyl carbamates and carbonates with high regio- and stereo­selectivity.