One-Pot Synthesis of Dihydroimidazo- and Imidazophenanthridinium Salts
11 September 2007 (eFirst)
Two highly efficient and general one-pot annulation reactions are described for the synthesis of dihydroimidazo- and imidazophenanthridinium salts (DIPs + and IPs +). These two methodologies exploit the difference in reactivity between primary amino-based or ammonia nucleophiles and the dielectrophilic starting material, 2-bromoethylphenanthridinium bromide.
annulation reaction - heterocycles - phenanthridinium derivatives - DNA intercalating agents - anticancer agents