Synthesis 2007(20): 3257-3260  
DOI: 10.1055/s-2007-983830
PSP
© Georg Thieme Verlag Stuttgart · New York

A Conjugate Reduction Pathway to Chiral Silanes Using CuH

Bruce H. Lipshutz*, Ching-Tien Lee, Benjamin R. Taft
Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA
Fax: +1(805)8938265; e-Mail: Lipshutz@chem.ucsb.edu;
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Publikationsverlauf

Received 28 March 2007
Publikationsdatum:
30. Juli 2007 (online)

Abstract

Experimental details concerning asymmetric 1,4-reduction of β-silylated-β,β-disubstituted enoates catalyzed by CuH are described. High yields and enantiomeric excesses are to be expected when Solvias’ JOSIPHOS bis-phosphine PPF-P(t-Bu)2 is used as a nonracemic ligand.

10

Catalog # L14561. PMHS purchased from Acros does not give the same results.

15

See http://www.solvias.com/.