Synthesis of Amino-Functionalized 2,2′-Bipyridines

Marko Hapke; Holger Staats; Ivonne Wallmann; Arne Lützen

doi:10.1055/s-2007-983824

PAPER

Synthesis of Amino-Functionalized 2,2′-Bipyridines

Marko Hapke^b, Holger Staats^a, Ivonne Wallmann^a, Arne Lützen*^a
^a Kekulé-Institute of Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk-Straße 1, 53121 Bonn, Germany
^b Leibniz-Institut für Katalyse e.V., Universität Rostock, Albert-Einstein-Straße 29a, 18059 Rostock, Germany
Fax: +49(228)739608; e-Mail: arne.luetzen@uni-bonn.de;

Abstract

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Abstract

Amino-functionalized 2,2′-bipyridines are versatile building blocks for the synthesis of sophisticated chelating ligands with the 2,2′-bipyridine core. The 4-, 5-, and 6-substituted 2-chloro- and 2-bromopyridine building blocks were prepared and coupled to symmetrically and non-symmetrically diamino-functionalized compounds by homo- and cross-coupling procedures. Further transformations were carried out to demonstrate the synthetic versatility of these compounds and the employed procedures.

Key words

cross-coupling reactions - bipyridine - palladium - protecting group - amines

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