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Synthesis 2007(15): 2287-2290  
DOI: 10.1055/s-2007-983792
PAPER
© Georg Thieme Verlag Stuttgart · New York

Single-Step Synthesis of Functional Organic Receptors via a Tridirectional Minisci Reaction

Prakash B. Palde, Brian R. McNaughton, Nathan T. Ross, Peter C. Gareiss, Charles R. Mace, Robert C. Spitale, Benjamin L. Miller*
Department of Dermatology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
Fax: +1(585)2731346; e-Mail: Benjamin_Miller@urmc.rochester.edu;
Further Information

Publication History

Received 8 March 2007
Publication Date:
12 July 2007 (online)

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Abstract

A key goal of synthetic organic chemistry is the preparation of functional molecules from simple starting materials as expeditiously as possible. Building on our efforts to construct tripodal receptors featuring a cis-1,3,5-cyclohexane core, we have employed a tridirectional Minisci-type radical alkylation reaction as a single-step method for the production of a series of new putative receptors.

Key words

radicals - receptors - bioorganic chemistry - heterocycles - host-guest systems

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Palde, P. B.; Gareiss, P. C.; Miller, B. L., manuscript in preparation.