The palladium(II) chloride catalyzed cross-coupling of arylboronic acids with carboxylic
anhydrides or acyl chlorides in water in the presence of various surfactants is described.
The inexpensive and industrially widely used sodium dodecyl sulfate (SDS) was found
to be a good promoter of the coupling reaction and aryl ketones were obtained in good
yields without the use of phosphine ligands. The reactions were unaffected by the
presence of electron-releasing and electron-withdrawing substituents in both the arylboronic
acids and carboxylic derivatives and a variety of aryl ketones were obtained under
mild conditions in air.
aryl ketone - boronic acid - carboxylic anhydride - acyl chloride - palladium catalysis